The latest trainer for How to Survive 2 seems to make all the quests where you have to open doors (there are a lot in the sewers
) not doable since you can't interact with the doors with the trainer activated.
EDIT: So I found out that as long as you don't use the 1 hit damage, it works fine, so just don't use that one, and all the others work, and you can open doors, and you don't fail missions that require you to escort an npc, and also enemies can't 1 shot your defenses either