I have this problem as well with all my mrAntifun trainers, will only work one time in the game with the correct version, and if I close the game and try to play on another occasion, the trainer will make a sound, but won't activate. This has been my experience with mrAntifun trainers. Am not new to using trainers I've been using trainers for well over ten years.
WIndows 10 user, But it also happened when I use windows 7.
- Start the game first then sensitive. The trainer (Done nothing changed)
- In some games, you would have to use the function in the game before activating the related cheat,e.g., shoot a bullet then activate unlimited ammo cheat.(No difference Trainer won't activate)
- Make sure the trainer was made for the game version you are using, Many of the trainers we have work on multiple versions of the game however other games are version sensitive . ( Same Version)
And this happens to me in various games. Tropico 5, Stellaris, Crusader Kings II, Divinity Original Sin 2, Vail Of Crows, Tyranny, Power & Revolution - Geo-Political Simulator 4, Oriental Empires, Long Live the Queen, ETC just to mention a few that only worked 1 time (the moment I downloaded it) and then it never worked again without any updates or changes.